Short-chain fructooligosaccharide regulates hepatic peroxisome proliferator-activated receptor alpha and farnesoid X receptor target gene expression in rats.

Fukasawa , T. and Kamei, A. and Watanabe , Y. and Koga , J. and Abe , K. (2010) Short-chain fructooligosaccharide regulates hepatic peroxisome proliferator-activated receptor alpha and farnesoid X receptor target gene expression in rats. Journal of Agricultural and Food Chemistry, 58 (11). pp. 7007-7012.

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Abstract

Prebiotic short-chain fructooligosaccharide (scFOS) is known to have various beneficial effects in humans and animals. Using a nutrigenomic approach, we have previously identified marker genes for the intestinal immunomodulatory and lipid-lowering effects of scFOS. The present study aimed to predict novel physiological effects of scFOS through nutrigenomic analyses. DNA microarray analysis revealed that administration of scFOS changed the expression of the nuclear receptors peroxisome proliferator-activated receptor alpha (PPARalpha) and farnesoid X receptor (FXR) target genes in the rat liver. Gene expression analysis provided some new interesting hypotheses, for instance, the possible improvement of bile secretion via FXR target genes, and regulation of amino acid metabolism and the urea cycle via PPARalpha and/or FXR target genes. Our findings clearly indicated that nutrigenomics may make it possible to screen for novel physiological effects of dietary ingredients.

Item Type: Article
Additional Information: We are grateful to Prof. Ryuichiro Sato (The University of Tokyo) and Prof. Hisanori Kato (The University of Tokyo) for pertinent discussions on the results of DNA microarray analysis.
Uncontrolled Keywords: Fructooligosaccharide, nutrigenomics, DNA microarray, PPARR and FXR target genes
Author Affiliation: Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd, Japan.
Subjects: Animal Husbandary > Veterinary Sciences
Divisions: General
Depositing User: Mr Arbind Seth
Date Deposited: 21 Nov 2012 10:01
Last Modified: 21 Nov 2012 10:01
Official URL: http://dx.doi.org/10.1021/jf1006616
URI: http://eprints.icrisat.ac.in/id/eprint/8846

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