Risk Estimates of Liver Cancer Due to Aflatoxin Exposure from Peanuts and Peanut Products

Dichter, C. R. (1984) Risk Estimates of Liver Cancer Due to Aflatoxin Exposure from Peanuts and Peanut Products. Food Chemical Toxicology, 22 (6). pp. 431-437.

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Abstract

An assessment was undertaken of the risk of liver cancer in the USA associated with aflatoxin ingestion from peanuts. Both laboratory-animal data and epidemiological data collected from the scientific literature and several prominent mathematical extrapolation techniques were used. Risk estimates differed by a factor of > 1000 when the extrapolated results of three selected animal studies were analysed. Dose-response data for the male Fischer rat, the most sensitive mammalian species studied, produced an estimate of 158 cases of liver cancer per year in the USA at current levels of aflatoxin exposure. An estimate of 58 annual cases was predicted on the basis of epidemiological data of populations in Africa and Thailand.

Item Type: Article
Additional Information: This research was supported by grants from the Interdisciplinary Programs in Health and the Department of Nutrition, Harvard School of Public Health.
Uncontrolled Keywords: Liver Cancer, Aflatoxin, Peanut.
Author Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Subjects: Postharvest Management > Food Technology
Divisions: Groundnut
Depositing User: Mr Siva Shankar
Date Deposited: 16 Aug 2012 11:51
Last Modified: 16 Aug 2012 11:52
URI: http://eprints.icrisat.ac.in/id/eprint/7402

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