Jayashree, T. and Subramanyam, C.
(2000)
Oxidative Stress as a Prerequisite for Aflatoxin Production by Aspergillus Parasiticus.
Free Radical Biology & Medicine, 29 (10).
pp. 981-985.
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Abstract
The relevance of free radical generation and oxidative stress with regard to aflatoxin production was
examined by comparing the oxygen requirement and antioxidant status of a toxigenic strain of Aspergillus parasiticus
with that of a nontoxigenic strain at early (trophophase) and late logarithmic (idiophase) growth phases. In comparison
to the nontoxigenic strain, wherein the oxygen requirements were relatively unaltered at various growth phases, the
toxigenic strain exhibited greater oxygen requirements at trophophase coinciding with onset of aflatoxin production. The
activities of antioxidant enzymes such as xanthine oxidase, superoxide dismutase, and glutathione peroxidase and the
mycelial contents of thiobarbituric acid–reactive substances as well as of reduced glutathione were all enhanced during
the progression of toxigenic strain from trophophase to idiophase. The combined results suggest that aflatoxin
production by the toxigenic strain may be a consequence of increased oxidative stress leading to enhanced lipid
peroxidation and free radical generation.
| Item Type: |
Article
|
| Uncontrolled Keywords: |
Aflatoxin, Aspergillus parasiticus, Free radicals, Oxidative stress |
| Author Affiliation: |
Department of Biochemistry, University College of Science, Osmania University, Hyderabad, India |
| Subjects: |
Plant Protection |
| Divisions: |
General |
| Depositing User: |
Mr Siva Shankar
|
| Date Deposited: |
09 Aug 2012 08:43 |
| Last Modified: |
09 Aug 2012 08:44 |
| URI: |
http://eprints.icrisat.ac.in/id/eprint/7274 |
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