Rao, J. P. and Sashidhar, R. B. and Subramanyam, C. (1998) Inhibition of aflatoxin production by trifluoperazine in Aspergillus parasiticus NRRL 2999. World Journal of Microbiology & Biotechnology, 14. pp. 71-75.
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Abstract
Tri¯uoperazine, an anti-calmodulin agent, inhibited a¯atoxin production by Aspergillus parasiticus NRRL 2999, without affecting the growth signi®cantly. Culturing the organism for 3 days in the presence of 0.14 mM tri- ¯uoperazine resulted in a generalized decrease in the production of all a¯atoxins; the production of a¯atoxin B1, a potent hepatocarcinogen, was inhibited to 88% under such conditions. Culturing 7-day-old preformed cultures in the presence of higher concentrations of tri¯uoperazine (>1 mM) completely abolished production of all a¯atoxins including AFB1. The inhibitory in¯uence of tri¯uoperazine on a¯atoxin production was accompanied by calmodulin- dependent phosphorylation of an 85 kDa cytoplasmic calmodulin-binding protein. While the functions of calmodulin in mediating primary events of germination, growth and differentiation in fungi have earlier been reported, the present results indicate a possible role for calmodulin in the production of fungal toxins.
| Item Type: | Article |
|---|---|
| Additional Information: | This research was supported by a research grant (SP/ SO/A-13/91) made available from the Department of Science and Technology, New Delhi |
| Uncontrolled Keywords: | A¯atoxin, Aspergillus parasiticus, calmodulin; protein phosphorylation, tri¯uoperazine. |
| Author Affiliation: | Department of Biochemistry, University College of Science, Osmania University, Hyderabad-500 007, Andhra Pradesh, |
| Subjects: | Soil Science and Microbiology > Microbiology Plant Physiology and Biochemistry > Biochemistry |
| Divisions: | General |
| Depositing User: | Mr Siva Shankar |
| Date Deposited: | 07 Aug 2012 09:49 |
| Last Modified: | 07 Aug 2012 09:50 |
| URI: | http://eprints.icrisat.ac.in/id/eprint/7217 |
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