Ogunka-Nnoka, C.U. and Uwakwe, A.A. and Nnabuike, C.J. (2012) Effects of Ethanolic /Potash Extract of Sorghum Bicolor Leaf Sheath on Serum Electrolytes, Liver and Kidney Indicative on Albino Rats. Journal of Natural Sciences Research, 2 (4). pp. 66-71.
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Abstract
Toxicity profile on serum electrolytes, hepatic and renal function indices on rats administered with mixture of ethanol/potash extract of sorghum bicolor leaf sheath were investigated. The ethanol/potash extract was dried and re-suspended in distilled water and the following quantities were administered orally to the albino rat per kg body weight: 1000, 2000 and 3000mg; while 0.9% normal saline was served to the control group. The blood was collected through cardiac puncture under chloroform anesthesia after 14 days. There after, the sera were analyzed for sodium (Na+), potassium, (K+),chloride (Cl-) ion, urea, creatinine, total protein, total bilirubin and cholesterol levels. Serum sodium levels, (176-297 mmol/L) were significantly (p<0.05) increased following extract treatments, while potassium ion decreased (6.54-4.00mmol/L). The extract increased chloride ion concentration (95.8-99.0mmol/L). The serum value for creatinine (0.08-0.32mmol/L) and urea (3.16-38mmol/L) increased progressively; while cholesterol (0.96-0.19mmol/L) and total protein (54.13-17.27g/L) levels, decreased significantly (p<0.05) when compared to the control values. No significant change was observed in the value obtained for bilirubin except at dose level of 3000mg/kg body weight. There was a progressive decrease in body weight after 14days administration of the extract. The result showed that the mixture of ethanol/potash extract of sorghum bicolor leaf sheath has been observed in rats under the conditions of this study to be toxic.
| Item Type: | Article |
|---|---|
| Author Affiliation: | Rivers State University of Science and Technology, Port Harcourt, University of Port Harcourt, Choba, Nigeria |
| Subjects: | Plant Protection Postharvest Management > Food Technology Statistics and Experimentation |
| Divisions: | Sorghum |
| Depositing User: | Mr. SanatKumar Behera |
| Date Deposited: | 07 Jul 2012 11:27 |
| Last Modified: | 07 Jul 2012 11:28 |
| Official URL: | http://www.iiste.org/Journals/index.php/JNSR/artic... |
| URI: | http://eprints.icrisat.ac.in/id/eprint/6623 |
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