Thomas, D. (2010) Gene–environment-wide association studies: emerging approaches. Nature Reviews Genetics, 11. pp. 259-272.
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Abstract
Despite the yield of recent genome-wide association (GWA) studies, the identified variants explain only a small proportion of the heritability of most complex diseases. This unexplained heritability could be partly due to gene–environment (G×E) interactions or more complex pathways involving multiple genes and exposures. This Review provides a tutorial on the available epidemiological designs and statistical analysis approaches for studying specific G×E interactions and choosing the most appropriate methods. I discuss the approaches that are being developed for studying entire pathways and available techniques for mining interactions in GWA data. I also explore methods for marrying hypothesis-driven pathway-based approaches with ‘agnostic’ GWA studies
| Item Type: | Article |
|---|---|
| Author Affiliation: | Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP‑220, Los Angeles, California 90089‑9011, USA |
| Subjects: | Crop Improvement > Genetics/Genomics |
| Divisions: | Other Crops |
| Depositing User: | Ms K Syamalamba |
| Date Deposited: | 27 Aug 2014 05:01 |
| Last Modified: | 27 Aug 2014 05:01 |
| Official URL: | http://dx.doi.org/0.1038/nrg2764 |
| URI: | http://eprints.icrisat.ac.in/id/eprint/13403 |
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