Conti, L. and Swarup, R. and Sadanandom, A. and et al, . (2014) Small ubiquitin-like modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin. Developmental Cell, 28 (1). pp. 102-110.
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Abstract
Plants survive adverse conditions by modulating their growth in response to a changing environment. Gibberellins (GAs) play a key role in these adaptive responses by stimulating the degradation of growth-repressing DELLA proteins. GA binding to its receptor GID1 enables association of GID1 with DELLAs. This leads to the ubiquitin-mediated proteasomal degradation of DELLAs and consequently growth promotion. We report that DELLA-dependent growth control can be regulated independently of GA. We demonstrate that when a proportion of DELLAs is conjugated to the Small Ubiquitin-like Modifier (SUMO) protein, the extent of conjugation increases during stress. We identify a SUMO-interacting motif in GID1 and demonstrate that SUMO-conjugated DELLA binds to this motif in a GA-independent manner. The consequent sequestration of GID1 by SUMO-conjugated DELLAs leads to an accumulation of non-SUMOylated DELLAs, resulting in beneficial growth restraint during stress. We conclude that plants have developed a GA-independent mechanism to control growth
| Item Type: | Article |
|---|---|
| Author Affiliation: | School of Biological and Biomedical Sciences, South Road, Durham University, Durham DH1 3LE, UK |
| Subjects: | Crop Improvement |
| Divisions: | Other Crops |
| Depositing User: | Ms K Syamalamba |
| Date Deposited: | 13 Feb 2014 08:55 |
| Last Modified: | 13 Feb 2014 08:55 |
| Official URL: | http://dx.doi.org/10.1016/j.devcel.2013.12.004 |
| URI: | http://eprints.icrisat.ac.in/id/eprint/12590 |
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