Rao, J.P. and Subramanyam, C. (1999) Requirement of Ca2+ for aflatoxin production: inhibitory effect of Ca2+ channel blockers on aflatoxin production by Aspergillus parasiticus NRRL 2999. Letters in Applied Microbiolology, 28 (1). pp. 85-88.
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Abstract
Aflatoxin production by Aspergillus parasiticus NRRL 2999 was inhibited when Ca2+ channel blockers, i.e., verapamil and diltiazem (> 1 mmol 1(-1)), were included in the culture medium. Inhibition was not accompanied by growth inhibition, nor was the [14C]-glucose uptake by the organism altered. However, both the compounds inhibited [14C]-acetate incorporation into aflatoxin B1 in a dose-dependent manner and decreased sporulation of the organism. Even though a nutritional role for Ca2+ has not been demonstrated unequivocally in fungi, the present study suggests the importance of Ca2+ in the production of these secondary metabolites
| Item Type: | Article |
|---|---|
| Additional Information: | SNNigam Collection |
| Author Affiliation: | Department of Biochemistry, Osmania University, Hyderabad, India |
| Subjects: | Plant Production Plant Protection |
| Divisions: | General |
| Depositing User: | Mr B Krishnamurthy |
| Date Deposited: | 08 Aug 2013 03:33 |
| Last Modified: | 08 Aug 2013 03:33 |
| Official URL: | http://dx.doi.org/10.1046/j.1365-2672.1999.00460.x |
| URI: | http://eprints.icrisat.ac.in/id/eprint/11364 |
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