Nanjundiah, V. (1993) Why are most mutations recessive? Journal of Genetics , 72 (2-3). pp. 85-97.
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Abstract
It is a long-standing observation that most mutations are recessive. That is, they do not lead to visible phenotypic effects when in heterozygous combination with the wild-type allele. The reason for this has long been debated. Fisher [The genetical theory of natural selection. Oxford, UK; Clarendon Press, 1930] attributed the observed dominance of the wild type to the action of natural selection at modifier loci. Wright [American Naturalist (1929) 63, 556-561], on the other hand, asserted that dominance did not have a selective function per se, but was a more or less automatic offshoot of genetic regulatory mechanisms. The present essay discusses these explanations from a contemporary standpoint and suggests that neither is likely to be valid exclusively. In particular, even when physiology appears to offer a sufficient explanation, evolution of dominance cannot be ruled out
| Item Type: | Article |
|---|---|
| Additional Information: | SNNigam collections |
| Author Affiliation: | Developmental Biology and Genetics Laboratory, Indian Institute of Science, Bangalore 560 012, India. |
| Subjects: | Plant Protection Crop Improvement |
| Divisions: | General |
| Depositing User: | Mr T L Gautham |
| Date Deposited: | 27 Jul 2013 11:11 |
| Last Modified: | 27 Jul 2013 11:11 |
| Official URL: | http://dx.doi.org/10.1007/BF02927924 |
| URI: | http://eprints.icrisat.ac.in/id/eprint/11233 |
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