Using markers in gene introgression breeding programs

Hospital, F. and Chevalet, C. and Mulsant, P. (1992) Using markers in gene introgression breeding programs. Genetics, 132 (4). pp. 1199-1210.

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Abstract

The use of marker genes to hasten the reduction in the proportion of the donor genome in recipients during an introgression breeding programme was studied. The effects of the number of generations, intensity of selection, population size, and number and position of selected markers were studied for chromosomes carrying or not carrying the introgressed gene. Marker-assisted selection was found to result in a gain in time of about 2 generations, an efficiency below previous theoretical predictions. Markers were most useful when their map position was known. For early generations, results were as follows: (1) increasing the number of markers over 3 per non-carrier chromosome did not improve efficiency; (2) the segment surrounding the introgressed gene was better controlled by rather distant markers unless high selection intensity was applied; (3) selection on this segment first reduced the selection intensity available for selection on non-carrier chromosomes. On the basis of these results, an optimal strategy is proposed for selection on the whole genome, making the most of available material and conditions (e.g. population size, fertility, gene map)

Item Type:	Article
Additional Information:	SNNigam Collection
Author Affiliation:	Laboratoire de Génétique Cellulaire, Institut National de la Recherche Agronomique, Centre de Toulouse, 31326 Castanet, France
Subjects:	Crop Improvement
Divisions:	General
Depositing User:	Mr B Krishnamurthy
Date Deposited:	18 Apr 2013 06:28
Last Modified:	18 Apr 2013 06:28
Official URL:	http://www.genetics.org/content/132/4/1199.abstrac...
URI:	http://eprints.icrisat.ac.in/id/eprint/10284

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